Lupine Publishers | Scholarly Journal of Food and Nutrition
Abstract
Everyday people take their cars into
the mechanic to be worked on. Sometimes it’s for routine maintenance, other
times it’s because a warning light has come on or something just doesn’t feel
or sound right when the car is running. People frequently visit their doctors
for the same reason. Either something just doesn’t feel right – perhaps an
unusual ache or pain, sometimes that pain is in your chest - or one of your
blood tests (warning lights) came back in an abnormal range. Your doctor will
frequently run blood tests looking for a problem, much like the mechanic will
check the oil in your engine. Except the auto mechanic shuts the car off to run
his tests; something your doctor doesn’t have the luxury of doing. You can
infer a lot by looking at the engine oil, or getting a blood test. But you can
only infer something is going on. Neither the engine oil nor the blood test
tells you what the problem actually is – only hopefully where to look for the
answer to the problem When people get their cholesterol levels checked, it’s
usually because they’re worried about their heart – even though cholesterol by
itself doesn’t cause heart disease (Figure 1) – inflammation does. To begin
with you should also know there is more than one type of cholesterol in your
body.
The combination of these various
types of cholesterol, when put together, are called your total cholesterol
(TC). It’s the sum of your good (HDL) and bad (LDL) cholesterol, along with the
fats (triglycerides) in your blood, which are either made in your liver (very
low density lipoprotein cholesterol; VLDL) or consumed (fats and chylomicrons)
by you in the foods you eat. Another type of cholesterol is called intermediate
density lipoprotein cholesterol (IDL), because it is intermediate in density,
compared with the other types, and when compared with the other types of cholesterol
IDL is composed almost equally of cholesterol and fat.
TC = HDL + LDL + VLDL/5 +
Chylomicrons + IDL
You probably already realize this,
but you do need cholesterol for your body to work. You need cholesterol for
your cells to grow and maintain themselves and you need cholesterol for
hormones, for the lining of the axons of nerves in your body – including your
brain. You really don’t need to worry about eating it because your liver is
designed to make it. In fact, most people only absorb about 10% of the
cholesterol they eat, which means for most people, they are absorbing somewhere
between 25 and 50 mg each day from the food they eat. If you had to depend upon
that, you would probably either die or become seriously ill. Fortunately you
don’t need to depend upon what you absorb from the foods you eat, because your
liver will make around 1000 mg each day – 20 to 40 times the amount you get
from your diet – as long as you don’t have liver disease. One of the
interesting characteristics of carnivores is that their livers don’t make
cholesterol to meet their needs, so carnivores have to consume cholesterol from
the foods they eat to survive.
All this begs the question, if we
need cholesterol, why do so many doctors say cholesterol is bad for you? The
answer is both simpler and much more complex (Figure 1), than many people
think. Most foods that are high in cholesterol are also high in saturated fat
and it is this saturated fat, once oxidized, which is a primary, although not
only, cause of inflammation, within the walls of the arteries of the heart that
produces coronary artery (CAD)/heart disease [1,2], angina and death.
Increased dietary saturated fat
intake not only increases the amount of cholesterol made by your liver, but it
can also reduce the ability of cells in your body to remove the LDL cholesterol
(Figures 1 & 3) from the blood, by interfering with the LDL receptors
themselves–i.e., the part of your cells responsible for recognizing cholesterol
and removing it from the blood for use by the body. Just like insulin
receptors, which respond to increased levels of glucose (sugar) in the blood
stream, so too do the LDL receptors, respond to increased levels of LDL cholesterol.
However, there is no actual relationship between measured changes in blood
tests like cholesterol and measured changes in CAD [3], when physiologically
measured [4], as shown in (Figure 2) [2]. These changes cannot be measured
using mere coronary arteriograms [5]-the basis for most if not all of the
clinical data supporting the use of cholesterol lowering medicines - as
coronary arteriograms neither measure the ability of the coronary arteries to
respond to increased demand for coronary blood flow, nor the inflammation
within the walls of the arteries themselves. This is an extremely important
point and one that is frequently overlooked, given that up to 70% of all
myocardial infarctions (heart attacks) occur in people whose arteries have less
than 30% narrowing of the lumen – the area where the blood flows - and it is
only this lumen narrowing, which coronary arteriograms can evaluate.
What
types of foods raise your cholesterol levels?
While there are many studies which
reveal that many different types of diets may initially show improvements in
weight loss and blood cholesterol levels, most (not all) people would agree
that there are three basic types of foods, which have been associated with
increased cholesterol levels. These include:
a. Saturated Fat
b. Trans Fats, and
c. Highly refined, processed foods.
An increased consumption of any, or
a combination of these, can be associated with increased cholesterol levels,
increased insulin resistance, increased LDL receptor resistance, and increased
weightobesity. Consequently resulting in heart disease, strokes, diabetes and a
variety of other diseases. One of the common themes running through medicine
and social media is the belief, that medicines can solve your problems or at
least ameliorate them, thereby shifting the burden of responsibility. Something
Big Pharma and Big Food are all too happy to accept, as this shift in
responsibility results in profits for these corporations. Clearly you don’t
solve what you put in your mouth by putting something else in your
mouth–including medications or more of another type of food. You solve the
problem by not putting the first problem in your mouth.
While the approach of putting more
food or medications in your mouth is lucrative for Big Food and Big Pharma, it
has been disastrous for everyone else. Let’s be very clear here-there has not
been a shift in genetics in the last 100 years. Evolutionary mutations don’t
work that way and such changes when they do occur, provide a survival benefit
or they become extinguished. As Figure 4 shows [6], there is little, if any,
survival benefit from this increased expenditure of healthcare monies being
thrown at the problem and no appreciable increased life expectancy. One of, if
not the, major health care expenditure currently confronting us, is the cost of
prescription medications; with statins, PCSK9-inhibitors and diabetes
medications leading the way. Before we address how these medications work, lets
first look at the issue of cholesterol itself.
How
much cholesterol is too much?
People unfortunately have a tendency
to think of things in black and white, true false, right wrong - absolutes. For
decades physicians have talked about levels of cholesterol that we want to keep
your blood cholesterol below to reduce your risk of heart disease. The truth is
that there is no absolute value, which is safe for everyone. What may be safe
for you may kill someone else and vice-versa.
In the 1980’s and 1990’s, the first
author was a member of the American Heart Association - Physician Cholesterol
Education Faculty, and we used to tell people that total cholesterol levels
should be kept below 150 milligrams/deciliter (mg/dl or %) or 3.879 mmol/l
(millimole per liter) in standard international (SI) units. The use of this
number was somewhat arbitrary as 50% (half) of all people who have heart
attacks, have total cholesterol levels less than 150 mg/dl. At the same time,
other people with higher cholesterol levels do not have heart attacks. There
are a number of reasons for this including the differences in genetic handling
of cholesterol levels, the other factors involved in the inflammatory process
(Figure 1) and our sheer lack of real data about tissue levels of cholesterol
and CAD where the real problem lies, versus blood levels of cholesterol and
CAD.
The important take away point is
that oxidized cholesterol builds up in the walls of the arteries of the heart
and elsewhere, interfering with the ability of these arteries of the heart to
do their job and the result, which isn’t measured by looking at the cholesterol
in the blood, is a heart attack, stroke, loss of limb, etc. Cholesterol flowing
through the blood stream without depositing is not actually causing an issue,
at least not while flowing freely through the blood.
The
cholesterol causing heart disease isn’t the cholesterol floating around in your
blood stream to be sampled by your doctor
Only about 7% of your total BODY
cholesterol is found in your BLOOD. The remaining 93%, which we don’t measure,
is stored inside the cells of your body. Within the cells, the cholesterol is
being used for cell growth, repair and to make hormones along with other
substances needed by your body. It is also here where cholesterol is undergoing
oxidation and participating in the inflammation within the walls of your
arteries - where the real problem exists. When too much cholesterol is stored
in the walls of your arteries, and oxidized, inflammation will occur (Figure 1)
and these arteries will not be able to do their job. When that happens, you can
have a heart attack, stroke, need kidney dialysis or lose a limb. It will just
depend upon which artery is being damaged. The smaller the artery the sooner
the damage is likely to occur and be noticed.
LDL
receptor resistance is just as important, if not more so, than Insulin
resistance (Figures 1 & 3)
A lot of people are talking about
insulin resistance - the reason why many people ultimately develop diabetes.
When you have more sugar than the cells of your body need, the cells protect
themselves by becoming less responsive to the insulin. Less responsive =
insulin resistance.
The same thing happens with
cholesterol. Most, but not all, of your cholesterol is taken up for use by the
cells of your body via LDL cholesterol receptors. Just like the insulin
receptors for glucose (sugar), when the cells in your body don’t need more
cholesterol, the LDL cholesterol receptors become less response (Figure 3).
Less responsive = LDL resistance. When these LDL receptors become less
responsive, the LDL cholesterol remains in your blood stream longer, where with
time it becomes damaged (oxidized). This oxidized cholesterol can enter the
walls of the arteries which supply blood to your brain, heart, kidneys, liver;
in other words, everywhere. Once inside the walls of your arteries, this
oxidized cholesterol - which is an inflammatory irritant to the artery - is
taken up or consumed (phagocytized) by a special type of cell, called a
macrophage.
Macrophages are specialized cells
intended to protect your body. They are part of your defensive immune system
designed to fight disease and foreign invaders. By consuming the oxidized
cholesterol, the damaged cholesterol is removed from the wall of the arteries.
Unfortunately, this results in the death of these macrophages, which have died
in defense of your body; thus beginning an inflammatory build up within the
walls of your artery, which we call atherosclerosis - or coronary artery
(heart) disease.
This inflammatory buildup within the
walls of arteries interferes with the ability of the coronary arteries to relax
and carry more blood flow to the heart when needed [4,5]. This is
atherosclerosis and it is not seen by conventional cardiology tests. Coronary
arteriograms with their limitations and reliability problems [5], do not see
this buildup within the walls of the artery. Coronary calcium (CAC) scoring,
which looks for the presence of calcium – which may or may not be present
(Figure 1) - only sees calcium (if present) but tells us nothing about the
ability of the arteries to increase their blood flow when needed.
Both arteriograms and CAC scoring
are merely anatomic tests. They are limited to seeing a narrowing or calcium,
but their failure to see something and their inability to tell you what the
arteries are capable of doing [4], provide us limited information. Up to
eightyfive percent of people will have a heart attack due to the rupture of
this built up inflammatory material, inflammation, which began years earlier
within the walls of the arteries. As such the use of coronary arteriograms and
CAC scores for assessing the impact of cholesterol lowering drugs is extremely
limited and should be cautiously considered.
How
do the cholesterol lowering drugs work?
Ninety-three (93) percent of the
low-density lipoprotein (LDL) cholesterol in your body, the cholesterol we call
the bad cholesterol - because it is this cholesterol, which eventually causes
most of the harm to the arteries of your body once oxidized, causing heart
attacks, strokes and other major medical problems – is actually in the cells of
your body and not the blood stream. It is in the cells of your body, where this
LDL is needed – where it is actually being used for cell growth, repair,
hormone production, et cetera, where it cannot be measured. However, even too
much of a good thing, can be a problem.
This 93% of your body’s cholesterol
isn’t measured by sampling your blood for cholesterol. This cholesterol is
inside the cells and cannot be measured, at least without taking biopsies
(pieces) of your muscles, heart, brain, liver, et cetera. To get this LDL
inside your cells to be used requires, as we have mentioned, a special receptor
that recognizes the LDL - just like there are insulin receptors that recognize
insulin to bring glucose into the cells.
Many of the drugs physicians use to
lower your cholesterol, work either by slowing down how much cholesterol your
liver makes (that 1000 mg per day) or they work by trying to increase how much
LDL cholesterol is taken up from the blood, into the cells of your body. Just
because you lower the amount of LDL in your blood, doesn’t mean you are
reducing the amount of LDL in your body. In fact if you’re removing it from the
blood and putting it inside the cells, you’re clearly not removing it from the
body. The consequence of this is an increase in the amount of cholesterol
within the cells of the body proper. When those cells are within the walls of
the coronary arteries, inflammation can worsen promoting CAD. Coronary
arteriograms and CAC scores are not going to see this.
The main drugs for slowing the
production of cholesterol by your liver are HMG Co-A reductase inhibitors -
affectionately called statins. This is the slowest step in the production of
cholesterol by your liver. There is ample evidence that these drugs interfere
with co-enzyme Q 10, needed for normal cellular function. There is also
unpublished data, showing that damage to muscles, resulting from the use of
statins is much higher than previously thought, with studies showing muscle
damage even when blood tests for that muscle damage are not elevated.
Another older group of drugs,
included here for purpose of being complete, are the bile acid sequestrants.
These drugs work inside your gastrointestinal (GI) tract, where they combine
with the cholesterol in the bile secreted through your liver and gallbladder to
help digest fats you have eaten. By binding with the cholesterol in your bile,
the cholesterol is removed from your body when you evacuate your bowels. Thus
these drugs actually lower the total body cholesterol burden.
A relatively new group of drugs are
the PCSK9 inhibitors. These drugs are antibodies to proprotein convertase
subtilisin kexin9 (PCSK9). PCSK9 removes LDL receptors from your liver as part
of the naturally occurring clean up (recycling) sequence. The function of PCSK9
is to reduce the number of LDL receptors your liver has, which will reduce the
amount of LDL your liver can remove from your blood. Block this with a PCSK9
inhibitor, and the LDL receptors remain in place, resulting in more LDL being
removed from your blood by your liver; thereby lowering your blood LDL
cholesterol, while increasing your liver LDL cholesterol.
Finally, we have Niacin - also known as vitamin B3. Niacin
increases your good (HDL) cholesterol, which you can also do by exercising, not
smoking if you are a smoker and reduce the fats and refined foods in your diet.
Again, not putting the first thing in your mouth.
HDL is a scavenger mechanism. By
removing LDL from other parts of the body, HDL can reduce the level of LDL in
your blood - but not your body. HDL merely moves the cholesterol around from
one place to another, to be dealt with another day. In some instances, HDL can
actually harm your body. If the HDL is dysfunctional, which happens either due
to genetics or when you have diabetes, inflammation or oxidative stress, this
same HDL that was once thought to be only helpful, can actually be
pro-inflammatory and cause atherosclerotic heart disease.
Conclusion
The focus of using cholesterol
lowering medications, is to lower blood cholesterol levels. However, as we have
seen, the real harm occurs within the cells of the body and in particular
within the walls of the arteries, where inflammatory plaques result from a
combination of factors (Figure 1), including but not limited to oxidized LDL
cholesterol. By actually lowering the serum LDL levels, many of these drugs
work by increasing the uptake of LDL into the cells of the body proper.
The proposed benefit of these
medications, are based upon the lowering of blood LDL cholesterol levels, and
reported changes in coronary arteriograms. However, the lack of correlation
between changes in blood cholesterol levels and changes in measured physiologic
CAD [3] - by simply removing the LDL cholesterol from the blood and placing it
into the cells of the body where oxidation may occur – raise significant
questions as to the real cost benefit ratios of these drugs.
Given these limitations, it would
appear that greater emphasis should be placed on lowering total body
cholesterol burden, either through the use of medications which actually lower
LDL body cholesterol levels, or through dietary and lifestyle changes which
limit the oxidative impact of LDL cholesterol in addition to the other
components (Figure 1) responsible for inflammatory coronary artery disease.
Acknowledgment
FMTVDM is issued to the first
author. The “Inflammation and Heart Disease” theory was developed by the first
author. All figures reproduced with the expressed consent of the first author.
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